FENZISHI:C41H76N2O15 FENZILIANG：837.03

　　【SHIYINGZHENG】BENPINSHIYONGYUHUANONGXINGLIANQIUJUNYINQIDEYANYANJIBIANTAOTIYAN，MINGANJUNSUOZHIDEBIDOUYAN、ZHONGERYAN、JIXINGZHIQIGUANYAN、MANXINGZHIQIGUANYANJIXINGFAZUO，FEIYANZHIYUANTIHUOFEIYANYIYUANTISUOZHIDEFEIYAN;SHAYANYIYUANTIYINQIDENIAODAOYANHEGONGJINGYAN;MINGANXIJUNYINQIDEPIFURUANZUZHIGANRAN。

　　【XINGZHUANG】BENPINWEIBOMOYIPIAN，CHUQUBAOYIHOUXIANBAISEHUOLEIBAISE。

　　【YAOLIDULI】BENPINWEIBANHECHENGDE14YUANHUANDAHUANNEIZHILEIKANGSHENGSU。KANGJUNPUYUKANGJUNZUOYONGJIBENSHANGYUHONGMEISUXIANGFANG，DUIGELANYANGXINGJUNDEZUOYONGJIAOHONGMEISULVECHA，DUISHIFEIJUNTUANJUNDEZUOYONGJIAOHONGMEISUQIANG。DUIFEIYANYIYUANTI、FEIYANZHIYUANTI、RONGNIAONIAOYUANTIDEKANGWEISHENGWUZUOYONGYUHONGMEISUXIANGFANGHUOLVEQIANG。 BENPINKETOUGUOXIJUNXIBAOMO，ZAIJIEJINGONGTI(“P”WEI)YUXIJUNHETANGTIDE50SYAJICHENGKENIXINGJIEHE，ZUDUANLEZHUANYIHETANGHESUAN(t-RNA)JIEHEZHI“P”WEISHANG，TONGSHIYEZUDUANLEDUOTAILIANZISHOUWEI(“A”WEI)ZHI“P”WEIDEZHUANYI，YINERXIJUNDANBAIZHIHECHENGSHOUDAOYIZHI。

　　【YAODAIDONGLIXUE】KOUFUXISHOUHAO，XUEYAOFENGNONGDU(Cmax)GAO，DANJILIANGKOUFULUOHONGMEISU150 mgHOUYUE2XIAOSHIDAXUEYAOFENGNONGDU(Cmax)WEI6.6～7.9mg/L，JINSHIKESHISHENGWULIYONGDUXIAJIANGYUEYIBAN。FENBUGUANG，BIANTAOTI、BIDOU、ZHONGER、FEI、TAN、QIANLIEXIANJIQITAMINIAOSHENGZHIDAOZUZHIZHONGDEYAOWUNONGDUJUNKEDAYOUXIAOZHILIAOSHUIPING。QIDANBAIJIEHELVZAIXUENONGDU2.5mg/LSHIWEI96%。YIYUANXINGJI5GEDAIXIEWUCONGTINEIPAICHU，7.4%ZINIAOYEPAICHU。XUEXIAOCHUBANSHUAIQI(t1/2β)WEI8.4-15.5XIAOSHI。

　　【YONGFAYONGLIANG】KONGFUKOUFU，YIBANLIAOCHENGWEI5-12RI。CHENGRENYICIYIPIAN(150mg)，YIRI2CI;YEKEYICI2PIAN(300mg)，YIRI1CI。ERTONGYICIANTIZHONG2.5-5mg/kg，YIRI2CI。

　　【BULIANGFANYING】ZHUYAOBULIANGFANYINGWEIFUTONG、FUXIE、EXIN、OUTUDENGWEICHANGDAOFANYING，DANFASHENGLVMINGXIANDIYUHONGMEISU。OUJIANPIZHEN、PIFUSAOYANG、TOUHUN、TOUTONG、GANGONGNENGYICHANG(ALTJI ASTSHENGGAO)、WAIZHOUXUEXIBAOXIAJIANGDENG。

　　【JINJI】DUIBENPIN、HONGMEISUHUOQITADAHUANNEIZHILEIYAOWUGUOMINZHEJINYONG。

　　【ZHUYISHIXIANG】

　　1.GANGONGNENGBUQUANZHESHENYONG。YANZHONGGANYINGHUAZHEDEXUEXIAOCHUBANSHUAIQI(t1/2β)YANZHANGZHIZHENGCHANGSHUIPING2BEIYISHANG，RUQUESHIXUYAOSHIYONG，ZEYICIJIYAO1PIAN，YIRI1CI。

　　2.QINGDUSHENGONGNENGBUQUANZHEBUXUZUOJILIANGDIAOZHENG，YANZHONGSHENGONGNENGBUQUANZHEJIYAOSHIJIANYANZHANGYIBEI(YICIJIYAO1PIAN，YIRI1CI)。

　　3.BENPINYUHONGMEISUCUNZAIJIAOCHANAIYAOXING。

　　4.WEIHUODEJIAOGAOXUEYAONONGDU，BENPINXUKONGFU(CANQIAN1XIAOSHIHUOCANHOU3-4XIAOSHI)YUSHUITONGFU。

　　5.FUYAOQIJIANDINGQIJIANCEGANGONGNENG。

　　【YUNFUJIBURUQIFUNVYONGYAO】YUNFUJIBURUQIFUNVSHENYONG。DIYU0.05%DEJIYAOLIANGPAIRUMURU，SUIRANYOUBAODAODUIYINGERDEYINGXIANGBUDA，DANRENGXUKAOLVSHIFOUZHONGZHISHOURU。

　　【LAONIANHUANZHEYONGYAO】RULAONIANRENDEYAODONGXUEWUMINGXIANGAIBIAN，BUXUDIAOZHENGJILIANG。

　　【YAOWUXIANGHUZUOYONG】

　　1.BUYUMAIJIAOAN、ERQINGMAIJIAOAN、XIUYINTING、TEFEINEIDING、TONGKANGZUOJIXISHABILIPEIWU。

　　2.DUIANCHAJIANDEDAIXIEYINGXIANGXIAO，DUIKAMAXIPING、HUAFALIN、LEINITIDINGJIQITAZHISUANYAOJIBENWUYINGXIANG。

　　【GUIGE】150mg(15WANDANWEI)

　　【ZHUZANG】MIFENG，ZAIGANZAOCHUBAOCUN。

　　【BAOZHUANG】LVSUPAOZHAOBAOZHUANG，6PIAN/BAN，1BAN/HE。

　　【YOUXIAOQI】ERNIAN

　　【PIZHUNWENHAO】GUOYAOZHUNZI H20053725